Charles R. Cantor

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Construction of a genetic toggle switch in Escherichia coli

Timothy S. Gardner, Charles R. Cantor, James J. Collins
Nature
2000

It has been proposed that gene-regulatory circuits with virtually any desired property can be constructed from networks of simple regulatory elements. These properties, which include multistability… (More)

Noise in eukaryotic gene expression

William J. Blake, Mads Kærn, Charles R. Cantor, James J. Collins
Nature
2003

Transcription in eukaryotic cells has been described as quantal, with pulses of messenger RNA produced in a probabilistic manner. This description reflects the inherently stochastic nature of gene… (More)

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

A new type of gel electrophoresis separates DNA molecules up to 2000 kb with resolutions exceeding the logarithmic molecular weight dependence of conventional electrophoresis. The technique uses 1.5%… (More)

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.

Mathias Ehrich, Matthew R. Nelson, +6 authors Dirk van den Boom
Proceedings of the National Academy of Sciences…
2005

Methylation is one of the major epigenetic processes pivotal to our understanding of carcinogenesis. It is now widely accepted that there is a relationship between DNA methylation, chromatin… (More)

Phenotypic consequences of promoter-mediated transcriptional noise.

William J. Blake, Gábor Balázsi, +6 authors James J. Collins
Molecular cell
2006

A more complete understanding of the causes and effects of cell-cell variability in gene expression is needed to elucidate whether the resulting phenotypes are disadvantageous or confer some adaptive… (More)

Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus.

Yuk Ming Dennis Lo, K. C. Allen Chan, +8 authors Rossa W. K. Chiu
Science translational medicine
2010

Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA fragments among primarily maternally derived DNA fragments. We sequenced a maternal plasma DNA sample at up to… (More)

Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale

Christopher D. Herring, Anu Raghunathan, +8 authors Bernhard O. Palsson
Nature Genetics
2006

We applied whole-genome resequencing of Escherichia coli to monitor the acquisition and fixation of mutations that conveyed a selective growth advantage during adaptation to a glycerol-based growth… (More)

Bacterial charity work leads to population-wide resistance

Henry Hing Cheong Lee, Michael Molla, Charles R. Cantor, James J. Collins
Nature
2010

Bacteria show remarkable adaptability in the face of antibiotic therapeutics. Resistance alleles in drug target-specific sites and general stress responses have been identified in individual… (More)

Whole-genome annotation by using evidence integration in functional-linkage networks.

Ulas Karaoz, T. M. Murali, +4 authors Simon Kasif
Proceedings of the National Academy of Sciences…
2004

The advent of high-throughput biology has catalyzed a remarkable improvement in our ability to identify new genes. A large fraction of newly discovered genes have an unknown functional role,… (More)

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.

Rossa Wai Kwun Chiu, K. C. Allen Chan, +11 authors Y. M. Dennis Lo
Proceedings of the National Academy of Sciences…
2008

Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis. Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus sampling and… (More)

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