Charles Q. Choi

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Drosophila melanogaster flies concentrate behavioral activity around dawn and dusk. This organization of daily activity is controlled by central circadian clock neurons, including the lateral-ventral pacemaker neurons (LN(v)s) that secrete the neuropeptide PDF (pigment dispersing factor). Previous studies have demonstrated the requirement for PDF signaling(More)
BACKGROUND Neuropeptides regulate many biological processes. Elucidation of neuropeptide function requires identifying the cells that respond to neuropeptide signals and determining the molecular, cellular, physiological, and behavioral consequences of activation of their cognate G protein-coupled receptors (GPCRs) in those cells. As a novel tool for(More)
Class B1 (secretin family) G protein-coupled receptors (GPCRs) modulate a wide range of physiological functions, including glucose homeostasis, feeding behavior, fat deposition, bone remodeling, and vascular contractility. Endogenous peptide ligands for these GPCRs are of intermediate length (27-44 aa) and include receptor affinity (C-terminal) as well as(More)
Social cues contribute to the circadian entrainment of physiological and behavioral rhythms. These cues supplement the influence of daily and seasonal cycles in light and temperature. In Drosophila, the social environment modulates circadian mechanisms that regulate sex pheromone production and mating behavior. Here we demonstrate that a neuroendocrine(More)
Previous experiments have shown that individual bacteriophage infections of Escherichia coli cells have burst sizes ranging from a few phage to hundreds of phage. It was proposed that larger cells have more cellular machinery and can therefore support higher rates of phage production resulting in larger burst sizes. The effect of cell size on the ability of(More)
C . M O N T EA T H /H ED G EH O G H O U SE /M IN D EN P IC T U RE S/ G ET T Y Industrious, shy herbivores they may be, but the beavers of the Tierra del Fuego archipelago on the southern tip of South America are such a menace that scientists are planning the largest eradication project ever attempted. In the 1940s, 50 North American beavers (Castor(More)