Charles Prince

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Vascular lesions resulting from injury are characterized by a thickening of the intima brought about in part through the production of increased amounts of extracellular matrix proteins by the vascular smooth muscle cells (VSMCs). In this study, we tested the hypothesis that cGMP-dependent protein kinase (PKG), an important mediator of NO and cGMP signaling(More)
The extracellular matrix of the normal adult brain lacks expression of most of the adhesive glycoproteins that are known to promote cell attachment, and it has been thought that the malignant invasion of astrocytoma tumor is mediated primarily by remodeling of the matrix by the tumor cells. It has been reported, however, that normal brain neuropil does(More)
Mandated requirements to share information across different sensitivity domains necessitate the design of distributed architectures to enforce information flow policies while providing protection from malicious code and attacks devised by highly motivated adversaries. The MYSEA architecture uses component security services and mechanisms to extend and(More)
BACKGROUND Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important to re-examine the role of this polysaccharide in bone homeostasis. DISCUSSION Previously published(More)
In this paper we discuss the design and implementation of GATutor, a graphical tutorial system for genetic algorithms (GA). The X Window/Motif system provides powerful tools for the development of a user interfaces with a familiar feel and look. We implemented the Traveling Salesman Problem (TSP) and the Set Covering Problem (SCP) as two example GA problems(More)
We previously reported that H-ras-induced metastatic ability in murine NIH 3T3 cells is accompanied by increased expression of osteopontin (OPN). OPN is a secreted phosphoprotein that contains a GRGDS amino acid sequence, suggesting adhesive function, but the function of OPN in tumor cells remains poorly understood. Here we report that PAP2 cells(More)
In this paper we analyze several Crowd-Sourced Serious Games (CSSGs), a new genre focused on advancing widely respected causes such as social equality and science. We observe that the general effectiveness of these games has remained largely unknown. Existing performance analyses have been limited to documenting experiences with individual systems. More(More)
We previously reported that H-ras-induced metastatic ability in murine NIH 3T3 cells is accompanied by increased expression of osteopontin (OPN). OPN is a secreted phosphoprotein that contains a GRGDS amino acid sequence, suggesting adhesive function, but the function of OPN in tumor cells remains poorly understood. cells thus not only secrete increased(More)
To study the role of la,25-dihydroxyvitamin I), (calcitrici) in tumor promotion, we used JB6 C141.Sa cells, a mouse epidermal cell model of tumor promotion. The phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA) irreversibly induces anchorage-independent growth and (urn-origenicity in these cells. Since we previously showed (hat calcitrici does not(More)
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