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(25"om the [PatAological Laborectory of the l~tslt iIYedwal College.) there appeared an article by B. R. Schenck " On Refractory Subcu-taneous Abscesses caused by a Fungns possibly related to the Sporo-trieha." "The primary point of infection was on the index finger, whence it extended up the radial side of the arm, following the lymph channels, and giving(More)
Th2 cells drive protective immunity against most parasitic helminths, but few mechanisms have been demonstrated that facilitate pathogen clearance. We show that IL-4 and IL-13 protect against intestinal lumen-dwelling worms primarily by inducing intestinal epithelial cells (IECs) to differentiate into goblet cells that secrete resistin-like molecule (RELM)(More)
The molecular mechanisms that drive mucosal T helper type 2 (T(H)2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for(More)
PURPOSE To evaluate if automatic atlas-based lymph node segmentation (LNS) improves efficiency and decreases inter-observer variability while maintaining accuracy. METHODS AND MATERIALS Five physicians with head-and-neck IMRT experience used computed tomography (CT) data from 5 patients to create bilateral neck clinical target volumes covering specified(More)
Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the common IL-4/IL-13R drives most mouse model pathophysiology, including airway hyperresponsiveness (AHR). However, the precise cellular mechanisms through which IL-4Rα induces AHR remain unclear. Overzealous bronchial smooth muscle(More)
Chemotaxis promotes neutrophil participation in cellular defense by enabling neutrophil migration to infected tissue and is controlled by persistent cell polarization. One long-standing question of neutrophil polarity has been how the pseudopod and the uropod are coordinated. In our previous report, we suggested that Rho GTPase Cdc42 controls neutrophil(More)
A number of efforts currently aim at scalable and efficient mobile ad hoc routing, an essential piece concerning the integration of such networks in the Internet. However, there is another independent and important issue, namely, how can existing Internet networks and ad hoc networks coexist coherently within the same protocol architecture. A fundamental(More)
Computer aided drug design is progressing and playing an increasingly important role in drug discovery. Computational methods are being used to evaluate larger and larger numbers of real and virtual compounds. New methods based on molecular simulations that take protein and ligand flexibility into account also contribute to an ever increasing need for(More)
Genome-wide screening and positional cloning have linked neuropeptide S receptor 1 (NPSR1) with asthma and airway hyperresponsiveness. However, the mechanism by which NPSR1 regulates pulmonary responses remains elusive. Because neuropeptide S and its receptor NPSR1 are expressed in brain regions that regulate respiratory rhythm, and Npsr1-deficient mice(More)
Taxol, 1-ß-D-arabinofuranosy Icytosine (ara-C), and etoposide induce apoptosis in HL-60 cells that is blocked by overexpression of Bcl-2 or Ikl-\,, A ~60-amino acid "loop" domain of Bcl-2 and Bcl-xLthat contains phosphorylation sites is known to negatively regulate their antiapoptotic function. These findings indicate that the loop domain is necessary for(More)