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Pharmacokinetics of fleroxacin following single and multiple dosing were studied in healthy male volunteers. The characteristics of this new trifluorinated quinolone are the long elimination… (More)
Fleroxacin (Ro 23-6240; AM-833) is a new trifluorinated quinolone exhibiting high activity against a broad spectrum of gram-negative and gram-positive bacteria. Healthy male volunteers received,… (More)
A high-performance liquid chromatographic method for the determination of tenoxicam (Ro 12-0068, I) and the hydroxy metabolite Ro 17-6661 (II) in human urine has been developed. The parent drug and… (More)
Abstract A liquid chromatographic method is described for the determination of the new fluoroquinolone Ro 23–6240 and its N-demethyl and N-oxide metabolites in plasma and urine. The three substances… (More)
byalongelimination half-life (9to10h)andhighconcentrations inplasma (e.g., maximumconcentration of2.3,ig/ml after anoral doseof200mg).Thevolume ofdistribution clearly exceeds 1liter/kg andsuggests… (More)