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  • A.S.L. Caldwell, Leah J. Middleton, +5 authors Kirsty A. Walters
  • Biology, Medicine
  • Endocrinology
  • 2014 (First Publication: 30 May 2014)
  • Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age, causing a range of reproductive, metabolic and endocrine defects including anovulation, infertility, hyperandrogenism,Expand
  • Miriam Haywood, Jenny Spaliviero, Mark Jimemez, Nicholas J. C. King, David J Handelsman, Charles M. Allan
  • Biology, Medicine
  • Endocrinology
  • 2003 (First Publication: 1 February 2003)
  • We recently created a novel transgenic (tg) model to examine the specific gonadal actions of FSH, distinct from LH effects, by expressing tg-FSH in gonadotropin-deficient hypogonadal (hpg) mice.Expand
  • Kirsty A. Walters, Charles M. Allan, +5 authors David J Handelsman
  • Biology, Medicine
  • Endocrinology
  • 2007 (First Publication: 1 August 2007)
  • The role of classical genomic androgen receptor (AR) mediated actions in female reproductive physiology remains unclear. Female mice homozygous for an in-frame deletion of exon 3 of the Ar (AR(-/-))Expand
  • Charles M. Allan, Alvaro Juan Ojeda Garcia, +4 authors David J Handelsman
  • Medicine, Biology
  • Endocrinology
  • 2004 (First Publication: 1 April 2004)
  • Defining the gonadal effects of FSH distinct from those of LH remains difficult. We have characterized and compared the level of Sertoli and germ cell development in three mouse models recentlyExpand
  • S. Shih, Charles M. Allan, Sharon Grehan, Elizabeth Tse, Cathal J. Moran, John M. Taylor
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000 (First Publication: 13 October 2000)
  • Two distal enhancers that specify apolipoprotein (apo) E gene expression in isolated macrophages and adipose tissue were identified in transgenic mice that were generated with constructs of the humanExpand
  • Mark J. McCabe, Charles M. Allan, Caroline F.H. Foo, Peter K. Nicholls, Kirsten J. McTavish, Peter G. Stanton
  • Biology, Medicine
  • Biology of reproduction
  • 2012 (First Publication: 1 August 2012)
  • ABSTRACT Sertoli cell tight junctions (TJs) form at puberty as a major component of the blood-testis barrier (BTB), which is essential for spermatogenesis. This study characterized the hormonalExpand