Charles M. Zelen

Learn More
Our purpose was to compare healing characteristics of diabetic foot ulcers treated with dehydrated human amniotic membrane allografts (EpiFix®, MiMedx, Kennesaw, GA) versus standard of care. An IRB-approved, prospective, randomised, single-centre clinical trial was performed. Included were patients with a diabetic foot ulcer of at least 4-week duration(More)
A prospective, randomised, controlled, parallel group, multi-centre clinical trial was conducted at three sites to compare the healing effectiveness of treatment of chronic lower extremity diabetic ulcers with either weekly applications of Apligraf(®) (Organogenesis, Inc., Canton, MA), EpiFix(®) (MiMedx Group, Inc., Marietta, GA), or standard wound care(More)
BACKGROUND Allogeneic grafts derived from amnion/chorion are known to be efficacious in healing chronic diabetic foot ulcerations (DFUs). The goal of this study was to compare aseptically processed dehydrated human amnion and chorion allograft (dHACA) versus standard of care (SOC) in facilitating wound closure in nonhealing DFUs. METHODS Patients with(More)
Advanced therapies such as bioengineered skin substitutes (BSS) and dehydrated human amnion/chorion membrane (dHACM) have been shown to promote healing of chronic diabetic ulcers. An interim analysis of data from 60 patients enrolled in a prospective, randomised, controlled, parallel group, multi-centre clinical trial showed that dHACM (EpiFix, MiMedx Group(More)
Arthrodesis of the first metatarsocuneiform joint is a powerful and durable procedure to help correct moderate to severe hallux valgus and/or first ray hypermobility. However, painful nonunion remains a notoriously high potential outcome. Research regarding locking plates seems promising, and data show lower rates of nonunion. Innovative fixation techniques(More)
For lesser toe deformities, fusion of the proximal interphalangeal joint offers good long-term correction and predictability. Digital arthrodesis has been described for longer than 100 years in the literature, and current techniques closely resemble those described in early accounts. However, many implants currently being used take advantage of the latest(More)
The surgical correction of hallux valgus has evolved since it was first described. Many osteotomies and fixation methods have been described and results have improved. Innovative new fixation methods include the Mini TightRope, new absorbable implants, and plating options. This article discusses the evolution of capital osteotomies as well as the evolution(More)
Unsuccessful healing represents a significant medical dilemma for both patients and clinicians and create a financial burden on the health care system. Despite the efforts of physicians, many injuries fail to heal with standard care alone. For decades human amniotic membrane composed of both amnion and chorion has shown remarkable therapeutic potential, but(More)
BACKGROUND In a recently published, prospective randomized controlled trial (RCT) comparing aseptically processed dehydrated human amnion/chorion allograft (dHACA) to standard of care (SOC), 85% wound closure rates were reported in the dHACA arm while only 25% of patients in the SOC arm healed. OBJECTIVE The purpose of this retrospective crossover study(More)
Currently there are a number of surgical techniques being utilized to address the entity of symptomatic, recalcitrant retrocalcaneal exostosis. This article presents a mechanical study of a modified surgical approach which has been developed at the Northern Virginia Podiatric Residency Program for the purposes of complete resection of all offending(More)