Charles M. Kinzig

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The pharmacology of leukotrienes (LT) C4 and D4 in isolated airway smooth muscle was investigated. In rat trachea, neither LTC4 or D4 elicited a response. In contrast, LTC4 was a potent contractile agonist in guinea-pig trachea, bronchus and parenchymal lung strip. Similar effects were obtained with LTD4 in trachea and parenchyma. In trachea and bronchus,(More)
The [3H]leukotriene C4 ([3H]LTC4) and [3H]leukotriene D4 ([3H] LTD4) specific binding sites in guinea-pig lung membranes were characterized and correlated with smooth muscle contractile activities of a series of LTC-, D- and E-type analogs. [3H]LTC4 bound to the specific sites with high affinity (dissociation constant Kd = 15 +/- 5 nM), saturable capacity(More)
Lisa Jorgenson STMicroelectronics, Inc. Directors Steven Arnold Micron Technology, Inc. Edward Blocker Koninklijke Philips N.V. Tina M. Chappell Intel Corp. William J. Coughlin Ford Global Technologies LLC Robert DeBerardine Sanofi-Aventis Anthony DiBartolomeo SAP AG Louis Foreman Enventys Scott M. Frank AT&T Darryl P. Frickey Dow Chemical Co. Krish Gupta(More)
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