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  • Charles J Sherr
  • Biology, Medicine
  • Science
  • 1996 (First Publication: 6 December 1996)
  • Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a)Continue Reading
  • Dawn E. Ouelle, Frédérique Zindy, Richard A. Ashmun, Charles J Sherr
  • Medicine, Biology
  • Cell
  • 1995 (First Publication: 1 December 1995)
  • The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the retinoblastoma protein (pRB) and prevents exitContinue Reading