Charles J Hoff

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OBJECTIVES Teaching hospitals are perceived to provide a higher quality of care for the treatment of rare disease and complex patients. A substantial proportion of stage I palliation for hypoplastic left heart syndrome (HLHS) may be performed in nonteaching hospitals. This study compares the in-hospital mortality of stage I palliation between teaching and(More)
STUDY OBJECTIVE To describe repeat pregnancy among adolescents and to compare those who experienced a repeat pregnancy to those who did not. DESIGN, SETTING, PARTICIPANTS Retrospective case control of all adolescents who entered and exited the Teen Mother & Child Program, a multidisciplinary clinic for pregnant and parenting teens and their children,(More)
Selected characteristics of the social environment are tested as predictors of children's risk for obesity. Data were collected during the summer of 1991 at the University of South Alabama Springhill Paediatric Clinic (Mobile, AL, USA). Data were collected on 77 children, aged 2.5-5 years, and their primary caretaker. Obesity risk was measured by the(More)
OBJECTIVES To describe the efficacy of intrathecal baclofen (ITB) therapy in the management of spasticity in young children with cerebral palsy (CP) and to identify risk factors for complications. DESIGN Consecutive case series of 25 implanted ITB delivery systems during a 48-month period. SETTING Pediatric specialty hospital and outpatient department.(More)
OBJECTIVE The risk of serious bacterial infection (SBI) in febrile infants who are classified as low risk (LR) or high risk (HR) by the Rochester criteria has been established. LR infants average a 1.4% occurrence of SBI, whereas HR infants have an occurrence of 21%. The occurrence of SBI in Rochester LR or HR infants with confirmed viral infections is(More)
OBJECTIVE To determine the possible role of the immune system in the pathogenesis of endometriosis. DESIGN The lymphocyte proliferative response in the presence of autologous endometrial cells was assayed by tritiated thymidine incorporation. SETTING Patients were recruited from a university outpatient clinic. MAIN OUTCOME MEASURE To determine the(More)
Referrals for deformational plagiocephaly (DP) have increased, but estimates of its actual prevalence vary, depending on the population studied and criteria for diagnosis. Few studies employ an objective technique for diagnosis. The objectives of this study were to validate the Transcranial Diameter Difference (TDD) and, using it, determine the prevalence(More)
Homeostasis is maintained primarily by the parasympathetic nervous system and is thought to provide a physiological substrate for the development of complex behaviors. This investigation was undertaken to test the hypothesis that infants with high parasympathetic tone are more efficient regulators of homeostasis than infants with low parasympathetic tone.(More)
We have studied the epidemiology of inguinal hernias in preterm infants. Inguinal hernias occur with increased frequency in infants less than or equal to 32 weeks' gestational age or less than or equal to 1,250 g birth weight. Among infants less than or equal to 32 weeks' gestational age, intrauterine growth retardation significantly increases the risk for(More)
Prostate cancer remains the most common male malignancy in Western countries, yet limited information exists regarding genetic changes and clinical correlations. The advent of comparative genomic hybridization microarray (GM) technology has recently allowed for precise screening of DNAs for genetic copy number changes; this offers an advantage over previous(More)