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A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it… Continue Reading
Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1),… Continue Reading
ErbB3 is an important regulator of tumorigenesis and is implicated in development of resistance to several currently used oncology drugs. We have identified ErbB3 inhibitors based on a novel biologic… Continue Reading
Flt3 is a class 111 tyrosine kinase receptor expressed on primitive human and murine hematopoietic progenitor cells (HPC). In previous studies using stroma-free short term assays, Ftt3 ligand (FL)… Continue Reading
ErbB3 is an important regulator of tumorigenesis and is implicated in development of resistance to several currently used oncologydrugs.Wehave identifiedErbB3 inhibitors based on anovel biologic… Continue Reading