Charles Haberkern

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To the Editor:—Firth and Head 1 1 are to be congratulated for providing a comprehensive review of the pathophysiology of sickle cell disease and erudite discussion of its implications for anesthesiologists. We also appreciate their attempts to apply evidence-based knowledge to our understanding of the perioperative care of these patients. Although this will(More)
A term neonate was being treated with intravenous phenytoin. To maintain a serum level above 10 micrograms per milliliter and abolish seizure activity, it was necessary to carry out repeated serum concentration measurements, administer several loading doses, and administer an unusually large maintenance dose (25 mg per kilogram per day), divided into a(More)
The effect of acute graded hypoxemia on the electroencephalogram (EEG) of five prematures and five full term Macaca nemestrina in the neonatal period was determined using power spectral analysis--a technique that obviates the limitations of visual inspection. The EEG of selected epochs was analyzed by a Fast Fourier Transform program (POWER) during the 20(More)
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