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Previous studies in rats have demonstrated that large lesions in the medial preoptic area (MPOA) disrupt all aspects of maternal behavior. In the present study, small bilateral electrolyte lesions in the MPOA of lactating females abolished nest building and retrieving components of maternal behavior while crouching and nursing were unaffected. Animals which(More)
In lactating female rats bilateral parasagittal cuts transecting the dorsolateral neural connections of the medial preoptic area (MPOA) abolished nest building and retrieving components of maternal behavior, while crouching and nursing were unaffected. While few animals with these cuts were suckled when presented with pups the prolactin secretion response(More)
Anatomical aspects of aminergic neurons contained within or projecting to the hypothalamus have been studied with the Falck-Hillarp fluorescence method, the glycoxylic acid technique, Palkovits' "punch-out" system with radioenzymatic assays, electron microscopy (EM), and immunocytochemical localization of the synthesizing enzymes with the light microscope(More)
The effects of depletion of hypothalamic norepinephrine (NE) during late pregnancy on the postpartum ovulatory LH surge, the onset and maintenance of maternal behavior and lactation were examined in adult female rats. Bilateral transections of the ascending noradrenergic pathways (ANP) between days 14 and 17 of gestation resulted in a 70% depletion in(More)
In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH). NE was infused at a dosage known to(More)
Plasma LH levels and ovulation were studied in female rabbits following administration of several inhibitory analogues of luteinizing hormone-releasing hormone (LHRH) before and after mating with experienced males. Administration of (D-Phe2, D-Leu6)-LHRH (1.5 mg/kg sc) to does 30 min before mating did not prevent either LH release or ovulation. However, a(More)
Figure 14 summarizes some of the brain-pituitary-ovarian relationships which we have been discussing. Neurons in the arcuate nucleus of the hypophysiotropic area produce LRH which is secreted into the proximal capillary plexus of the hypophysio-portal system in the median eminence. LRH production is modulated in the rat and possibly also in the monkey by(More)