Charles H. Nelson

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The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor(More)
Oligonucleotide microarrays, also called "DNA chips," are currently made by a light-directed chemistry that requires a large number of photolithographic masks for each chip. Here we describe a maskless array synthesizer (MAS) that replaces the chrome masks with virtual masks generated on a computer, which are relayed to a digital micromirror array. A 1:1(More)
We collected and completely sequenced 32,127 full-length complementary DNA clones from Oryza sativa L. ssp. japonica cv. "Nipponbare." Mapping of these clones to genomic DNA revealed approximately 20,500 transcriptional units (TUs) in the rice genome. For each TU, we selected 60-mers using an algorithm that took into account some DNA conditions such as base(More)
BACKGROUND Until recently, few genomic reagents specific for non-human primate research have been available. To address this need, we have constructed a macaque-specific high-density oligonucleotide microarray by using highly fragmented low-pass sequence contigs from the rhesus genome project together with the detailed sequence and exon structure of the(More)
We present a simple kinematic model for the narrow-line region (NLR) of the Seyfert 1 galaxy NGC 4151, based on our previous observations of extended [O III] emission with the Space Telescope Imaging Spectrograph (STIS). The model is similar to a biconical radial outflow model developed for the Seyfert 2 galaxy NGC 1068, except that the bicone axis is(More)
We have obtained new Hubble Space Telescope (HST) observations of M84, a nearby massive elliptical galaxy whose nucleus contains a ≈ 1.5 × 10 9 M ⊙ dark compact object , which presumably is a supermassive black hole. Our Space Telescope Imaging Spectrograph (STIS) spectrum provides the first clear detection of emission lines in the blue (e.g., [O II] λ3727,(More)
Narrow-band imaging of the nuclear region of NGC 4151 with the Hubble Space Telescope is presented. The filter bandpasses isolate line emission in various high velocity ranges in several ions. Slitless and long-slit spectra of the region with the Space Telescope Imaging Spectrograph also indicate the locations of high velocity gas. These emission regions(More)
We present slitless spectra of the Narrow Line Region (NLR) in NGC 4151 from the Space Telescope Imaging Spectrograph (STIS) on HST, and investigate the kinematics and physical conditions of the emission line clouds in this region. Using medium resolution (∼ 0.5 ˚ A) slitless spectra at two roll angles and narrow band undispersed images, we have mapped the(More)
The volume and interplay of mass-transport (MTD) and turbidite-system deposits varies on different continental margins depending on local and external controls such as active-margin or passive-margin tectonic setting and climatic and/or sea-level change. Erosion and breaching of local grabens at the shelf edge of the southern Bering Sea produce giant,(More)
This dissertation consists of three essays that empirically investigate the role of regulatory pressures, voluntary 33/50 program and information spillover on firms' environmental performance. First, we examine the extent to which participating in the 33/50 program led to a reduction in 33/50 releases. Second, we examine the extent to which program(More)