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In cognitive neuroscience, functional magnetic resonance imaging (fMRI) is used to produce images of brain functions. These images play a central role in the practice of neuroscience. In this paper we are interested in how these brain images become understandable and meaningful for scientists. In order to explore this problem we observe how scientists use(More)
How participants to a joint activity come to develop a shared or mutual understanding of what they are perceiving has long been a problematic issue for philosophers, sociologists, and linguists. We examine the abstract model proposed by Clark and Marshall (1981) whereby speakers and hearers construct mutual knowledge and by which discrepancies in definite(More)
This paper examines embodied procedures for producing disagreement turns in the midst of the children's game of hopscotch. Turn shape, intonation, and body positioning are all critical to the construction of stance towards a player's move in the game. In particular, in formulating a player's move as ''out'' foul calls can state unambiguously, without doubt(More)
An omni-relevant issue for workplace studies is how participants engaged in joint activity make sense of the objects that constitute their shared material environment. In this study we examine a surgery taped in a teaching hospital to explore how formal procedures make relevant certain sorts of objects and, at the same time, are constituted through them. We(More)
Key Points • Compared with ubiquitously expressed PI3K p110a, genetic inhibition of PI3K p110d uniquely normalizes mutant Shp2-induced GM-CSF hypersensitivity. • Potent pharmacologic inhibitors of PI3K p110d cooperate with MEK inhibition to reduce mutant Shp2-induced hyperproliferation. Although hyperactivation of the Ras-Erk signaling pathway is known to(More)
Ferritin, a 24-mer heteropolymer of heavy (H) and light (L) subunits, is the main cellular iron storage protein and plays a pivotal role in iron homeostasis by modulating free iron levels thus reducing radical-mediated damage. The H subunit has ferroxidase activity (converting Fe(II) to Fe(III)), while the L subunit promotes iron nucleation and increases(More)
Mutations in the ferritin light chain (FTL) gene cause the neurodegenerative disease neuroferritinopathy or hereditary ferritinopathy (HF). HF is characterized by a severe movement disorder and by the presence of nuclear and cytoplasmic iron-containing ferritin inclusion bodies (IBs) in glia and neurons throughout the central nervous system (CNS) and in(More)