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In a previous paper Sharkey et al. (Bull Math Biol doi: 10.1007/s11538-013-9923-5 , 2012) proved the exactness of closures at the level of triples for Markovian [Formula: see text] (susceptible-infected-removed) dynamics on tree-like networks. This resulted in a deterministic representation of the epidemic dynamics on the network that can be numerically(More)
The epidermal growth factor receptor (EGFR) is a member of the tyrosine kinase group of growth factor receptors. Following the binding of ligands such as the epidermal growth factor (EGF) with EGFR, activation of signal transduction pathways can lead to changes in cellular proliferation and differentiation. EGFR is highly expressed by many tumors, and is(More)
Despite recent advances in the treatment of breast cancer, survival rates for patients with metastatic breast cancer remain poor, and new treatments are still required for both hormone-dependent and hormone-independent disease. The epidermal growth factor receptor (EGFR) is a promising new target for anticancer therapy because it is commonly highly(More)
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