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Manual circumlaryngeal therapy (manual laryngeal musculoskeletal tension reduction) was used to treat 25 consecutive functional dysphonia patients. Pre- and post-treatment audio recordings of connected speech and sustained vowel samples were submitted to auditory-perceptual and acoustical analysis to assess the immediate and long-term effects of a single(More)
Fatigue and weakness in the elderly are the functional consequences of underlying neuromuscular decline. However, little is known about the manifestations of aging in the larynx. This study evaluated the manner in which laryngeal senescence affects laryngeal-respiratory kinematics by videorecording laryngeal motion in both young and old rats. Recorded(More)
This study was designed to investigate how variations in patterns of injection could improve the efficacy of botulinum toxin injections in relieving the symptoms of adductor spasmodic dysphonia. A total of 64 adductor spasmodic dysphonia patients who were injected using indirect laryngoscopic localization (for a total of 426 injections) were analyzed(More)
The gross and microscopic anatomy of the rat larynx was studied with particular attention to myology and neuromuscular structures to further validate it as a model to evaluate morphologic and functional changes induced by botulinum injection. A laryngeal alar cartilage (LAIC), alar cricoarytenoid (ACA) muscle, and a superior cricoarytenoid muscle (SCA) were(More)
Nonlinear dynamic methods including correlation dimension and Lyapunov exponents are applied to quantitatively analyze phonations in excised larynx experiments. Irregular phonations are typically characterized by aperiodic waveforms and broadband spectra. Finite correlation dimensions and positive Lyapunov exponents of irregular phonations demonstrate the(More)
Arytenoid adduction is a phonosurgical procedure in which the arytenoid cartilages are approximated to reduce posterior glottal gap size and improve voice. Voice outcomes following arytenoid adduction are not always optimal. The goal of this study was to systematically vary suture direction and force of pull on the arytenoid cartilages in a human excised(More)
Several lines of evidence suggest aberrant immune response in schizophrenia, including elevated levels of cytokines. These cytokines are thought to be produced by activated microglia, the innate immune cells of the central nervous system. However, increase in translocator protein 18 kDa (TSPO), a marker of activated glia, has not been found in patients with(More)