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We have recently developed a wide-field photon-counting detector having high-temporal and high-spatial resolutions and capable of high-throughput (the H33D detector). Its design is based on a 25 mm diameter multi-alkali photocathode producing one photo electron per detected photon, which are then multiplied up to 10 7 times by a 3-microchannel plate stack.(More)
Synopsis Amyloid ȕ-protein (Aȕ 1) is believed to cause Alzheimer's disease (AD). Aȕ42 is substantially more neurotoxic than Aȕ40 and this increased toxicity correlates with existence of unique Aȕ42 oligomers. Met 35 oxidation to sulfoxide or sulfone eliminates the differences in early oligomerization between Aȕ40 and Aȕ42. Met 35 oxidation to sulfoxide was(More)
Advances in molecular technologies and automated instrumentation have provided many opportunities for improved detection and identification of microorganisms; however, the upstream sample preparation steps needed to apply these advances to foods have not been adequately researched or developed. Thus, the extent to which these advances have improved food(More)
1353 T ype 2 diabetes and its complications are a major cause of morbidity and mortality in adults. In 1992, patients with diabetes constituted 4.5% of the U.S. population but accounted for 14.6% of total U.S. health care expenditures (1). Approximately 1 in 7 health care dollars is currently spent on caring for diabetic individuals, and 95% of these(More)
Normal development depends on specific genetic and environmental inputs. When environments change, entire populations of organisms may simultaneously express maladaptive phenotypes. Selection in the new environment may gradually restore the ancestral phenotype by favouring alleles that counteract the environmental perturbation. This evolutionary process is(More)