Charles E. Meyers

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The explosive growth in the availability of information is overwhelming traditional information management systems. Although individual pieces of information have become easy to find, the larger context in which they exist has become harder to track. These contextual questions are ideally suited to visualization since the human visual system is remarkably(More)
No new chemotherapy agents have been developed recently that present hope for improving survival in patients with colon or rectal cancer. We undertook this study to investigate a new route of administering an old drug, 5-fluorouracil (5-FU). Sixty-six patients with advanced primary colon or rectal cancer were randomized to receive 12 cycles with increasing(More)
Light-cured glass ionomers with an initial set of 20 seconds may produce higher initial bond strengths, as well as decreased sensitivity to moisture contamination and desiccation, than chemically cured glass ionomers making them attractive for use as orthodontic bonding agents. The purpose of this study was to determine and compare the shear bond strength(More)
The mandibular position indicator (MPI) was used to compare condylar position between centric relation (CR) and centric occlusion (CO) for 107 patients before orthodontic treatment. The MPI data were examined to determine frequency, direction, and magnitude of CO-CR difference; and data were analyzed for possible correlation to the patient's Angle(More)
BACKGROUND Suramin is an anthelmintic drug that recently has been shown to have clinical efficacy in the treatment of patients with some advanced malignancies, including prostate carcinoma. The current study was done to assess the effect of suramin at clinically relevant doses on the growth in culture of a human prostatic carcinoma cell line, PC-3. (More)
Clinical studies were prospectively conducted to quantitate the toxic side-effects of 5-FU administered by either the intravenous (i.v.) or intraperitoneal (i.p.) route. Sixty-six patients were treated following resection of a primary large bowel cancer after randomization to receive 5-FU by i.p. or i.v. routes. In both groups of patients, the dose of drug(More)
There have been reports of adrenal failure in patients treated with suramin, an agent that has recently been used as therapy for acquired immune deficiency syndrome. We conducted this study to assess the effect of suramin on adrenal function and structure in a primate, the cynomolgus monkey. Five male monkeys were treated with suramin (800 mg/m2, im) once a(More)