Charles Dempsey

Learn More
BACKGROUND Tyrosine hydroxylase (TH) regulates dopamine (DA) bioavailability. Its product, L-DOPA, is an established treatment for Parkinson's disease (PD), suggesting that TH regulation influences locomotion. Site-specific phosphorylation of TH at ser31 and ser40 regulates activity. No direct evidence shows that ser40 phosphorylation is the dominating(More)
Dopamine is a vigorously studied neurotransmitter in the CNS. Indeed, its involvement in locomotor activity and reward-related behaviour has fostered five decades of inquiry into the molecular deficiencies associated with dopamine regulation. The majority of these inquiries of dopamine regulation in the brain focus upon the molecular basis for its(More)
Accurate estimates of precipitation type and amount are important for water management at the Salt River Project (SRP) located in Arizona. The primary focus of water operations at the SRP is management of reservoirs on the Salt and Verde Rivers. Knowledge of precipitation accumulating in watersheds (WSs) has historically been provided by a network of rain(More)
Percutaneous intervention in patients with intracoronary thrombus continues to pose a significant clinical challenge. In this report, we describe the successful treatment of a 44-year-old patient with an extensive chronic thrombotic occlusion of the right coronary artery using a rheolytic thrombectomy catheter. Despite angiographic documentation of coronary(More)
OBJECTIVE Platelet dysfunction is a common cause of bleeding after coronary artery bypass graft (CAG) surgery. This prospective observational audit explored the effects of clopidogrel and aspirin on chest drain output for the first 24 hours after CAG surgery. METHODS During a 7 week period from July to Aug 2003, all patients who underwent CAG at the(More)
  • 1