Charles D. Bluestone

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We studied the efficacy of tonsillectomy, or tonsillectomy with adenoidectomy, in 187 children severely affected with recurrent throat infection. Ninety-one of the children were assigned randomly to either surgical or nonsurgical treatment groups, and 96 were assigned according to parental preference. In both the randomized and nonrandomized trials, the(More)
Tympanometry, a test of middle ear status new to clinical pediatrics, was carried out on 280 subjects, 10 days through 5 years of age. The tympanograms obtained were compared with otoscopic findings and, in 107 of the subjects, with findings at myringotomy. Seven distinct tympanometric curve types were identified and defined, based on their degree of(More)
Data collected from 1980 to 1989 by investigators at the Pittsburgh Otitis Media Research Center were examined to detect changes over time in the prevalence of bacteria isolated from middle ear effusions in patients with otitis media. The organisms isolated most commonly from the 7396 effusions cultured at the center were Streptococcus pneumoniae and(More)
CONTEXT Anatomical, physiological, and epidemiological data indicate that there may be a significant genetic component to prolonged time with and recurrent episodes of otitis media in children. OBJECTIVE To determine the genetic component of time with and episodes of middle ear effusion and acute otitis media (AOM) during the first 2 years of life. (More)
Despite advances in public health and medical care, chronic suppurative otitis media is still prevalent around the world. It is most common in developing countries and in certain high risk populations in developed nations, as well as among children who have tympanostomy tubes inserted. Since this chronic infection is caused by persistent acute otorrhea,(More)
Acoustic admittance testing was done on the ears of two groups of children. The first group was comprised of children undergoing myringotomy and tube surgery for treatment of chronic or recurrent otitis media, and the second group was comprised of hospital outpatients who were unscreened with respect to a history of middle ear disease and who were more(More)
Two types of Eustachian tube dysfunction can result in otitis media: obstruction and abnormal patency. Obstruction may be either functional or mechanical. Functional obstruction can result from persistent collapse of the Eustachian tube due to increased tubal compliance, an inadequate active opening mechanism, or both. Mechanical obstruction may be the(More)
The middle ear (ME) pressure of alert and anesthetized rhesus monkeys was monitored by serial tympanograms in order to determine the gas absorption process in the ME cavity. During the four-hour observation period the ME pressure showed small, random fluctuations around zero pressure in the alert animals, whereas in the anesthetized animals, following an(More)
In an effort to study the effects of experimental paralysis of tensor veli palatini (TVP) muscle on Eustachian tube (ET) function and middle-ear (ME) status, botulinum toxin A (Oculinum) was injected into the TVP muscles of 8 Rhesus monkeys. Tubal function was tested longitudinally in 2 animals with tympanostomy tubes using the forced-response test, while(More)