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Functional connectivity of the feline coerulospinal projection was delineated by utilizing the combined approaches of antidromic activation and electrical stimulation. We isolated 25 locus coeruleus (LC) neurons that were electrophysiologically identified and histologically verified and that could be driven by stimulating the spinal cord. Antidromicity of(More)
The present study revealed a consistent reduction of ventral root-induced recurrent inhibition of monosynaptic reflexes in both extensor (gastrocnemius-soleus) and flexor (common peroneal) motonuclei upon delivery of preconditioning stimuli to the locus coeruleus (LC) in decerebrate cats. The magnitudes of the LC-induced decrease in recurrent inhibition,(More)
Beta-amyloid protein (A beta) fragments have been shown to be neurotoxic and/or enhance neuronal vulnerability when injected into the hippocampus. We investigated alterations in monoamine contents, including norepinephrine (NE), 5-HT and dopamine (DA) in the rat locus coeruleus (LC) one week following the injection of beta-amyloid peptide fragment 25-35(More)
The present analysis describes the cellular mechanisms underlying the heightened membrane excitability of hindlimb flexor and extensor motoneurons upon stimulation of the locus coeruleus (LC) in unanesthetized, decerebrate cats. In a total of 73 cells, brief train stimuli to the LC at 50-300 microA intensity evoked one of 4 patterns of motoneuronal(More)
PURPOSE This study compares the incidence of complications in eyes undergoing 25-gauge versus 20-gauge vitreoretinal procedures. METHODS Retrospective case series. A chart review of consecutive patients who underwent primary 25-gauge (129 eyes) and 20-gauge (129 eyes) vitreoretinal surgery by four surgeons at a single center between September 2002 and(More)
Following transection of the thoracic spinal cord, in a decerebrate cat, the forelimbs exhibit an enhanced extensor stretch reflex while the ipsilateral flexion reflex is more difficult to elicit (Schiff-Sherrington Phenomenon). The hindlimbs on the other hand have an increased threshold for the extensor stretch reflex while flexion reflexes are hyperactive(More)
Considerable evidence exists demonstrating that beta-amyloid protein and its fragments 1-40 and 25-35 (beta (25-35)) are neurotoxic to cells in the rat hippocampus both in culture and in vivo. This neurotoxicity has been correlated to the aggregational state of the peptides. Previously we have shown that beta (25-35) produces a cavitational lesion in rat(More)