Charles C. N. Wang

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In this paper, the movement of bacteria, i.e. E. coli, is simulated based on the run and tumble model. The random walk parameters, such as the speed, tumbling frequency, run duration, and the turn angle between two successive runs were taken from experimental measurements; and use them to simulate the bacteria movement in cases of three different uniform(More)
Computer-aided drug design methodologies have proven to be very effective, greatly enhancing the efficiency of drug discovery and development processes. In this paper we describe how to integrate complex drug discovery problems and computational solutions via a semantic interface. In particular we describe a Structured Natural Language approach to chemical(More)
Several dynamic models of a gene regulatory network of the light-induced floral transition process in Arabidopsis have been developed to capture the behavior of gene transcription and infer predictions based on experimental observations. It has been proven that the models can make accurate and novel predictions, which generate testable hypotheses. Two major(More)
The upstream of genes are expected to contain many still unknown regulatory regions that can increase or decrease the expression of specific genes. The processes of mining distinctive patterns (region) are to extract maximal repeats (patterns) from the upstream DNA sequences of human genes, and then filter out the patterns whose class frequency distribution(More)
Web services have become increasingly important in biomedical research as tools that allow databases and algorithms to be accessed programmatically as computational components in programs. Various biomedical web services differ in their definitions and invocation protocols, as well as their communication and data formats and this presents a barrier to(More)
Cardiovascular disease (CVD) is group of diseases of<lb>the heart and blood vessels and a major global cause of death,<lb>with more people dying every year from CVDs than from any<lb>other cause. Therefore, controlling and preventing CVDs and<lb>their complex pathogenesis (i.e., influenced by genetic and<lb>lifestyle factors) has gained considerable(More)
The correlation between hip replacement (Hip-Repl) and chronic osteomyelitis (COM) has not been studied in Asian populations. Thus, we assessed Hip-Repl-related risk of developing COM via a population-based, nationwide, retrospective cohort study. The Hip-Repl cohort was obtained from Taiwan’s Longitudinal Health Insurance Database 2000, and included(More)