Charles C. Anunobi

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AIMS AND OBJECTIVE This study aims at correlating different digital rectal examination (DRE) abnormalities with histopathological results in patients with prostatic diseases. MATERIALS AND METHODS A prospective study of 236 patients who underwent prostate needle biopsy (PNB). Inclusion criteria were presence of abnormal DRE findings or elevated prostate(More)
BACKGROUND Advances in breast cancer (BC) research have demonstrated differences between black and white women with regarding tumour behaviour, patient outcome and response to treatment which can be explained by underlying genetic changes. The tumour suppressor gene p53 has been speculated to be involved in tumour biology of triple negative and/or basal(More)
Background. Black women with breast cancer (BC) in Nigeria have higher mortality rate compared with British women. This study investigated prognostic features of cell proliferation biomarker (Ki-67) in Nigerian breast cancer women. Materials and Methods. The protein expression of Ki-67 was investigated in series of 308 Nigerian women, prepared as a tissue(More)
BACKGROUND Among gynaecological cancers, ovarian malignancy is the most lethal, largely due to the fact that it is not diagnosed until late stage. Information concerning the frequency and pattern of ovarian tumours in Lagos is scant. OBJECTIVE To present a 10 year retrospective histologic study of ovarian tumours in Lagos, Nigeria. The aim is to document(More)
BACKGROUND Mortuary workers face hazards at work such as infectious diseases, chemical and psychosocial hazards among others. If workers are to participate in activities to safeguard their health, they must be aware of the risks at work. OBJECTIVE The objective of the study is to assess the awareness of occupational health hazards and to determine their(More)
Calvarial hemangiomas are rare benign tumours of the skull bone for which seizure as a presentation is unusual; neurological deficits are uncommon. We report a case of cavernous hemangioma of the parietal bone causing seizure disorder in a 47 year old man. The tumor was removed enbloc with satisfactory methylmethacrylate cranioplasty. Pathological(More)
BACKGROUND Mortuary workers like other health workers are exposed to blood borne pathogens at work. A baseline assessment is important to plan for programmes to safeguard the health of workers. The aim of this study is to determine exposure rates to blood among mortuary workers in teaching hospitals in South West Nigeria. METHODS A descriptive cross(More)
Benign prostatic hyperplasia (BPH) is a common health problem in ageing men. This study was carried out to investigate the protective effect of telmisartan on testosterone-induced BPH in rats. Fifty-four male Wistar rats (200-250 g) were randomly divided into nine groups (n = 6) and orally treated for 28 consecutive days: group 1 - vehicle normal, olive oil(More)
Clear cell meningiomas are an uncommon subtype of meningioma rarely seen in infancy. We report a case of clear cell meningioma in an 8-month-old male infant. He presented at the Lagos University Teaching Hospital, Lagos, Nigeria, in 2015 with persistent vomiting, poor feeding and failure to thrive over a four month period. Generalised hypertonia and(More)
Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone-induced BPH in rats. Male Wistar rats (200-250 g) were randomly divided into nine groups (n = 8) and orally(More)