Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions.… (More)
During embryonic development, vascular networks remodel to meet the increasing demand of growing tissues for oxygen and nutrients. This is achieved by the pruning of redundant blood vessel segments, which then allows more efficient blood flow patterns. Because of the lack of an in vivo system suitable for high-resolution live imaging, the dynamics of the… (More)
Of the major enterprise resource areas, only information (i.e., IT) lacks integrated vendor solutions such as those offered by SAP, Oracle, and PeopleSoft. The particular problems of an " ERP for IT " solution are examined and some initial directions are presented, covering enterprise architecture, IT service management, technical element management and… (More)
We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine's known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine… (More)
Prior practices such as waterfall software development, project management, and IT process frameworks are being questioned, and workforce requirements changing in response. IT education must keep current with these digital trends. Present programs and curricula do not adequately meet the rapidly emerging demand for digitally-skilled professionals. To… (More)
IT management is strongly influenced by the major process frameworks ITIL®, COBIT®, and CMMI®. 1 However, these frameworks are inconsistent with important tenets of Business Process Management thinking. Examples of this inconsistency are provided, including an analysis of ITIL®'s Value Network advocacy. Implications and consequences and an alternate… (More)
Currently, IT as a value chain is supported by fragmented data and processes, contained within functional silos, suffering from much redundancy and lack of integrity. Currently, IT as a value chain is supported by fragmented data and processes, contained within functional silos, suffering from much redundancy and lack of integrity.
1. Abstract The term metadata is commonly understood as " data about data, " but has been expanding and evolving into new domains. This new scope may be seen as essentially the information schema for the enterprise IT function as a whole. The Object Management Group and Distributed Management Task Force have established important standards in this area.… (More)