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The problem of ethnicity identification from names has a variety of important applications, including biomedical research, demographic studies, and marketing. Here we report on the development of an ethnicity classifier where all training data is extracted from public, non-confidential (and hence somewhat unreliable) sources. Our classifier uses hidden(More)
Despite existing vaccines and enormous efforts in biomedical research, influenza annually claims 250,000-500,000 lives worldwide, motivating the search for new, more effective vaccines that can be rapidly designed and easily produced. We applied the previously described synthetic attenuated virus engineering (SAVE) approach to influenza virus strain(More)
Genomes of RNA viruses contain multiple functional RNA elements required for translation or RNA replication. We use unique approaches to identify functional RNA elements in the coding sequence of poliovirus (PV), a plus strand RNA virus. The general method is to recode large segments of the genome using synonymous codons, such that protein sequences, codon(More)
Nalidixic acid has been used to interrupt DNA synthesis in exponentially growing cultures of E. coli B/r. Within three minutes after removal of the nalidixic acid block, premature rounds of chromosome replication are initiated at the normal origin of vegetative DNA synthesis. The new growing forks traverse the chromosome in about 40 minutes, the normal(More)
Adeno-associated virus (AAV) is a single-stranded parvovirus retaining the unique capacity for site-specific integration into a transcriptionally silent region of the human genome, a characteristic requiring the functional properties of the Rep 78/68 polypeptide in conjunction with AAV terminal repeat integrating elements. Previous strategies designed to(More)
The social sciences strive to understand the political, social, and cultural world around us, but have been impaired by limited access to the quantitative data sources enjoyed by the hard sciences. Careful analysis of Web document streams holds enormous potential to solve longstanding problems in a variety of social science disciplines through massive data(More)
The rates of cell growth and of DNA synthesis have been measured in synchronized cultures of Escherichia coli B/r growing with three different doubling times, from 27 to 80 min. Cell volume was found to increase linearly over the cell cycle, the rate of increase doubling at a precise cell age for each growth rate. The time at which the rate of cell growth(More)
Influenza claims 250,000-500,000 lives annually worldwide. Despite existing vaccines and enormous efforts in biomedical research, these staggering numbers have not changed significantly over the last two decades 1 , motivating the search for new, more effective, vaccines that can be rapidly designed and easily produced. Using influenza virus strain(More)
Large-scale analysis over historical news corpora provides us with unique opportunities to examine sociological issues with respect to local and mass media. In particular, we combine the Lydia named entity recognition system with an name-based ethnicity classification engine to examine issues of ethnic and geocentric sentiment/coverage bias in newspapers.(More)