Charles Andrew van Hasselt

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PURPOSE Nasopharyngeal carcinoma (NPC) is highly prevalent in southern China and characterized by a strong association with EBV. We aimed to detect EBV DNA and cancer-related gene promoter hypermethylation in nasopharyngeal (NP) brushing samples and provide a novel noninvasive approach for NPC detection. EXPERIMENTAL DESIGN Twenty-eight NPC cases and 26(More)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated disease with high prevalence in Southern Chinese. Using multiparametric flow cytometry, we identified significant expansions of circulating naïve and memory CD4+CD25(high) T cells in 56 NPC patients compared with healthy age- and sex-matched controls. These were regulatory T cells (Treg), as(More)
OBJECTIVE This study examines subjects' level of consciousness with bispectral analysis in sedation endoscopy of the upper airway. STUDY DESIGN A prospective study. SETTING University hospital. SUBJECTS AND METHODS Bispectral analysis levels recorded in natural sleep of 43 patients with obstructive sleep apnea during an overnight polysomnographic(More)
OBJECTIVES To investigate the prevalence of long-term dysphagia in patients treated for nasopharyngeal carcinoma (NPC) by radiotherapy. Study Design Questionnaire-based assessment, clinical examination, and videofluoroscopic assessment of 50 patients, ages 26 to 75 years (average, 49 years), treated for NPC 12 to 119 months (average, 56 months) previously(More)
Using 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cases are likely to be tumors with monosomy(More)
OBJECTIVES Although thyroid cancer occurs much more frequently in females, the role of sex hormones in thyroid carcinogenesis is unknown. In this study, it has been investigated how 17beta-oestradiol (E2) influenced proliferation and growth of thyroid cancer cells. MATERIALS AND METHODS Cell proliferation and its related molecules were examined in thyroid(More)
OBJECTIVES To establish the reliability and validity of the Chinese (Cantonese) version of the Tinnitus Handicap Inventory to measure the self-perceived handicapping effect and severity of the condition in patients with chronic tinnitus. DESIGN Cross-sectional psychometric validation study. SETTING Audiology clinics in a hospital setting. PARTICIPANTS(More)
A double blind trial, using lateral neck radiographs of 100 patients with proven impacted fish bones and 100 normal cases, was conducted to assess the sensitivity, specificity and positive predictive value of radiography for impacted fish bones. Values of 25.3%, 86.3% and 72.7% respectively were obtained. The results are correlated to the clinical findings(More)
Iodine is a key element in the synthesis of thyroid hormones and the process of iodine transport by thyroid cells is active. Iodine deficiency, which is a known risk factor for thyroid cancer, may result from inadequate dietary iodine or from defects in iodine transportation. In contrast, a sufficient supply of iodine can induce cell-cycle arrest and(More)
To assess the prevalence of use of Personal Cassette Players (PCP) among youths in a residential community in Hong Kong, we interviewed 487 youths aged 15-24 years who attended various activities in eight Youth Centres in Shatin, Hong Kong. 394 (81%) reported using the Personal Cassette Player regularly. The mean duration of PCP use was 2.8 years with a(More)