Adenoviral vectors are considered to be good gene delivery vectors for cancer gene therapy due to their wide host tissue range and cell cycle-independent infectivity. However, the disadvantages include the lack of specificity for cancer cells and the high liver accumulation in vivo. The human CXCR4 gene is expressed at high levels in many types of cancers,… (More)
•Primary invasive breast carcinoma can be found arising from within mammary-like glands in the vulva.•There is no standard management strategy for this rare disease; treatment recommendations should be similar to that for primary breast carcinoma.•The use of sentinel lymph node biopsy may offer another management option for this disease.
PURPOSE Despite the success of conditionally replicating adenoviruses in tumor models, clinical success has been limited when they are used as a single modality agent. Overcoming the disparity in efficacy between in vivo animal models and human use is a key hurdle for better conditionally replicating adenovirus therapy in humans. We endeavored to identify… (More)