Charles A. Kohl

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The mechanisms by which the paint constituent 2-nitropropane (2-NP) exerts genotoxicity and hepatocarcinogenicity are poorly understood. The hypothesis was tested that nitric oxide (NO) is a hepatic metabolic intermediate generated from 2-NP and/or its anionic tautomer propane 2-nitronate (P2N). Incubations of liver microsomes from phenobarbital-pretreated(More)
G O L D I E is a system that has been developed to provide the top-down control of the low and intermediate level processes that create and modify the intermediate-level descriptions of image data used in image interpretation. The basic control structure of GOLDIE is the schema, a declarative specification of control strategies invoked in response to a(More)
The Image Understanding Environment (IUE) project is a ve year program, sponsored by ARPA, to develop a common object-oriented software environment for the development of algorithms and application systems. to review the design of this system and provides an overview of the implementation eeort currently under-eeort has the goal of a full C++ implementation(More)
The hepatocarcinogenicity of acetoxime has been tentatively linked with its metabolic oxidation to the potent genotoxicant and carcinogen propane 2-nitronate (P2-N). In order to test the hypothesis that acetoxime is metabolized to P2-N, the oxime (20 mM) was incubated with liver microsomes from mice, rats and two humans. Ion-pair HPLC analysis of the(More)
The mutagenicity of 2-nitropropane in Salmonella typhimurium (strain TA100) was proportional to the pH (range 6.1-9.1) of the medium used for pre-incubation of the agent and for incubation of the agent with the Salmonella. The mutagenicity correlated with an enhanced rate of tautomerase to propane 2-nitronate at relatively high pH as measured by high(More)
1. The stabilities of the industrial chemical and constituent of cigarette smoke 2-nitropropane (2-NP) and its aci tautomer propane 2-nitronate (P2N) towards hepatic enzymes and proteins such as serum proteins and oxyhaemoglobin were investigated in vitro in biological (hepatocytes and subcellular liver fractions) and model systems (serum proteins,(More)
2-Nitropropane (2-NP) is a genotoxicant and hepatocarcinogen in rodents. Conversion to propane 2-nitronate (P2N), the anion of the tautomeric aci form of 2-NP, seems to be a pivotal part of the mechanism by which 2-NP causes its toxicity. We tested the hypothesis that the tautomeric equilibrium is influenced by enzymes in the liver, the target organ of 2-NP(More)
This paper presents the Image Understanding Environment (IUE) in the context of a number of image understanding problem domains. The intent is to demonstrate, via concrete examples , how the IUE can assist the user in solving real problems. The particular problems are chosen to provide a representative, rather than exhaustive, sampling of current vision(More)
Progress in the eld of Computer Vision/Image Understanding has long been hampered by the lack of standard software environments for research and application development. The Image Understanding Environment (IUE) is being implemented to provide a freely distributed standard software environment appropriate for a wide range of research and development(More)
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