Charles A Frolik

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The Cbfa1/Runx2 (referred to herein as Cbfa1) transcription factor has been shown to be essential for osteoblast differentiation and bone formation during embryogenesis. PTH given intermittently is a proven bone anabolic agent. Here, we investigated whether PTH regulates the expression and/or activity of Cbfa1 in osteoblastic cells and in a rat metatarsal(More)
Differentiation of Tera-2 human embryonal carcinoma cells by expo sure to 2.1 imi a-difluoromethylornithine resulted in changes in mor phology, a decrease in growth rate, and changes in the expression of SSEA-1 differentiation antigen. While the binding of 12SI-insulin-like growth factor I (IGF-I) remained relatively constant during differentia tion,(More)
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