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  • Charles A Dinarello
  • Biology, Medicine
  • Blood
  • 1991 (First Publication: 15 April 1991)
  • The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a variety ofExpand
  • Charles A Dinarello
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1994 (First Publication: 1 December 1994)
  • Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During theExpand
    Interleukin-6 (IL-6) shares several biologic properties with IL-1, including hematopoietin-1 activity and stimulation of T cells. Because many of their biologic activities overlap, we developed andExpand