Charlene Yuan

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Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in isolated myocardial mitochondria. Cocaine(More)
Morphological alterations of cardiac mitochondria have been observed in rats chronically treated with cocaine. Whether cocaine directly causes heart mitochondrial dysfunction remains unclear. The present study was undertaken to investigate the effect of cocaine on mitochondrial function in cultured myocardial cells. Cells were incubated with cocaine(More)
AIMS The aim of this study was to test the hypothesis that that a method of gastric electrical stimulation (GES) optimized to inhibit gastric motility was effective in reducing food intake in dogs. METHODS Female dogs with a gastric cannula and gastric serosal electrodes were studied in three experiments: (1) to determine the best parameters and locations(More)
Cocaine can produce both positive and negative inotropy. The mechanism of cocaine-induced negative inotropy is poorly understood. In order to evaluate the inhibitory effect of cocaine on myocardial contractility, its action on potassium chloride-induced depolarization, release of calcium from sarcoplasmic reticulum, and sarcolemmal sodium-calcium exchange(More)
It has been suggested that cocaine may be directly toxic to myocardial cells. The mechanism of the toxicity is not known. Because we found that cocaine and lidocaine shared similar patterns of cytotoxicity, a role for local anaesthesia in the cytotoxicity of cocaine was evaluated in cultured rat cardiomyocytes. The cells were incubated with cocaine or(More)
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