Charlene Weber

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Sensitization to continued nociceptive stimulation is supposed to be involved in the development of chronic pain at several levels of the CNS, but experimental studies investigating the perceptual dynamics of sensitization in humans are rare, and the diagnostic validity of experimental pain models is not known. The present study used a tonic heat paradigm(More)
A prospective study of the role of preoperative and routine follow-up colonoscopy in 75 patients with colon and rectal carcinoma disclosed that additional premalignant or malignant lesions were detected and successfully treated in 44 percent of patients. These included four synchronous and three metachronous carcinomas. Timely diagnosis and treatment of(More)
Anticoagulation with intravenous heparin has been the standard treatment for the management of gestational thromboembolic complications. Catheter-directed thrombolysis is an encouraging approach for the treatment of thromboembolic disease and has not been previously reported during pregnancy. One gravid woman with pulmonary embolism, critically ill, and(More)
Although hypertension has been shown to increase myointimal thickening after arterial injury, a similar effect of nicotine has not been demonstrated. To compare the influence of nicotine with the known effect of hypertension, a standard balloon catheter injury was created in the aortas of four groups of experimental animals. A preliminary group (P) (n = 11)(More)
Meningeal involvement of multiple myeloma is rare. A patient with multiple myeloma presented with bilateral abducens nerve palsies. In the MRI neither lytic skull lesions nor meningeal enhancement could be found. The diagnosis was based on CSF studies and cytology. A neurologic remission was achieved with intrathecal chemotherapy.
Objective: To study the influence of the lipase inhibitor orlistat on the pharmacokinetics of the antihypertensive drugs atenolol, furosemide, captopril and nifedipine. Methods: Four open-label, crossover studies were performed on six to eight healthy male volunteers. Orlistat was given in doses of 50 mg 3 times daily mid-meal for 7 (nifedipine and(More)
Myeloproliferative disorders (MPD) are associated with an increased risk for thrombembolic events. In this study, we examined the prognostic value of transcranial Doppler (TCD) microemboli detection regarding clinical events and correlated TCD findings with results of blood cell counts and platelet flow cytometry to gain insight into the composition of(More)