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Glyoxalase and Methylglyoxal as Biomarkers for Plant Stress Tolerance
Glyoxalases are known to play a very important role in abiotic stress tolerance. This two-step pathway detoxifies ubiquitously present cytotoxic metabolite methylglyoxal, which otherwise increases toExpand
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A unique Ni2+ -dependent and methylglyoxal-inducible rice glyoxalase I possesses a single active site and functions in abiotic stress response.
The glyoxalase system constitutes the major pathway for the detoxification of metabolically produced cytotoxin methylglyoxal (MG) into a non-toxic metabolite D-lactate. Glyoxalase I (GLY I) is anExpand
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Episodes of horizontal gene-transfer and gene-fusion led to co-existence of different metal-ion specific glyoxalase I
Glyoxalase pathway plays an important role in stress adaptation and many clinical disorders. The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requiresExpand
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M. tuberculosis Secretory Protein ESAT-6 Induces Metabolic Flux Perturbations to Drive Foamy Macrophage Differentiation
The Foamy Macrophage (FM) differentiation forms a major component of the host dependent survival axis of M. tuberculosis. The FM which are characterized by the intracellular accumulation of lipidExpand
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Methylglyoxal detoxification in plants: Role of glyoxalase pathway
Methylglyoxal (MG) is a potent cytotoxin being produced primarily as result of non-enzymatic reactions in the living systems. The toxicity of MG is believed to be due to its ability to carry outExpand
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Glyoxalases and stress tolerance in plants.
The glyoxalase pathway is required for detoxification of cytotoxic metabolite MG (methylglyoxal) that would otherwise increase to lethal concentrations under adverse environmental conditions. SinceExpand
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Analysis of global gene expression profile of rice in response to methylglyoxal indicates its possible role as a stress signal molecule
Methylglyoxal (MG) is a toxic metabolite produced primarily as a byproduct of glycolysis. Being a potent glycating agent, it can readily bind macromolecules like DNA, RNA, or proteins, modulatingExpand
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  • Open Access
Expression of abiotic stress inducible ETHE1-like protein from rice is higher in roots and is regulated by calcium.
ETHYLMALONIC ENCEPHALOPATHY PROTEIN 1 (ETHE1) encodes sulfur dioxygenase (SDO) activity regulating sulfide levels in living organisms. It is an essential gene and mutations in ETHE1 leads toExpand
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Proteomics of contrasting rice genotypes: Identification of potential targets for raising crops for saline environment.
High salinity is one of the major problems in crop productivity, affecting seed germination as well as yield. In order to enhance tolerance of crops towards salinity, it is essential to understandExpand
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Methylglyoxal, Triose Phosphate Isomerase, and Glyoxalase Pathway: Implications in Abiotic Stress and Signaling in Plants
Methylglyoxal (MG) is a cytotoxic metabolite inevitably produced as a side product of primary metabolic pathways via both enzymatic and non-enzymatic reactions. In plants, spontaneous generation ofExpand
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