Charalambos Pappas

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Alkylation of sensitive amino acids during synthesis of biologically important peptides is a common and well-documented problem in Fmoc-based strategy. Herein, we probed for the first time an unexpected S-alkylation of Cys-containing peptides that occur during the final TFA cleavage of peptides from the Wang solid support. Through a battery of approaches(More)
Correlations between hydrogen bonds and solvent effects on phenol -OH proton shieldings, temperature coefficients (Δδ/ΔT) and effects on OH diffusion coefficients for numerous phenolic acids, flavonols, flavones, and oleuropein derivatives of biological interest were investigated in several organic solvents and were shown to serve as reliable indicators of(More)
J.N. Corlett, S. Marks , R. Rimmer, R. Schlueter Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA, 94720 P. Bellomo, V. Bharadwaj, R. Cassel, P. Corredoura, P. Emma, R.K. Jobe, P. Krejcik, S. Mao, B. McKee, K. Millage, M. Munro, C. Pappas, T.O. Raubenheimer, S. Rokni, M.C. Ross, H. Schwarz, J. Sheppard, C.M. Spencer, R.C. Tighe, M. Woodley(More)
W. Corbett, R. Hettel, R. Akre, P. Bellomo, R. Boyce, L. Cadapan, R. Cassel, B. Choi, D. Dell’Orco, I. Evans, T. Elioff, R. Fuller, N. Kurita, J Langton, G. Leyh, C.Limborg, D. Macnair, D. Martin, E. Medvedko, C. Ng, Y. Nosochkov, J. Olsen, M. Ortega, C. Pappas, S. Park, H. Rarback, A, Ringwall, P. Rodriguez, J. Safranek, H. Schwarz, B. Scott, J. Sebek, S.(More)
Anabolic steroid administration and planned exercise have been the two main methods applied to improve the function and morphology of atrophied muscle tissue. The effects of these two factors-specifically nandrolone decanoate administration and exercise by swimming on muscle weight, EMG activity, work capacity and on contractile protein content of rat(More)
e14555 Background: Patients with metastatic CS experience a variety of symptoms due to increased serotonin (5-HT) produced by metastatic GI tumor cells. The enzyme tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the synthesis of 5-HT. Reducing 5-HT synthesis by TPH inhibition represents a new mechanism for potentially managing symptoms(More)
The management and analysis of large-scale datasets – described with the term Big Data – involves the three classic dimensions volume, velocity and variety. While the former two are well supported by a plethora of software components, the variety dimension is still rather neglected. We present the BDE platform – an easy-to-deploy, easy-to-use and adaptable(More)