Chaoying Yan

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The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate homeostasis. To assess the(More)
Background:Increased adiposity in visceral depots is a crucial feature associated with glucocorticoid (GC) excess. The action of GCs in a target tissue is regulated by GC receptor (GR) and 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) coupled with hexose-6-phosphate dehydrogenase (H6pdh). Glycogen synthase kinase-3β (GSK3β) is known to be a crucial(More)
OBJECTIVE We assessed the efficacy and safety of a weekly pegylated human growth hormone (PEG-rhGH) (Jintrolong) vs daily rhGH for children with growth hormone deficiency (GHD). DESIGN Phase II and III, multicenter, open-label, randomized controlled trials. METHODS 108 and 343 children with treatment-naive GHD from 6 hospitals in China were enrolled in(More)
Sepsis is one of the most common disease of mortality during neonatal period, especially infected by Listeria monocytogene (LM). If organisms were acquired in uterus, sepsis can lead to serious septicemia with a higher mortality than acquired after birth. Clinical datas were collected in 9 cases who suffered from sepsis caused by LM Following(More)
OBJECTIVE To find more effective diagnosis and treatment of NRDS through comparatively analyzing the different gestational neonates with respiratory distress syndrome in risk factors, clinical characteristics, treatment and prognosis. METHODS The clinical data of 232 neonates were retrospectively analyzed who had been admitted into the neonatal intensive(More)
OBJECTIVE To study the possibility of lower the nosocomial infection rate among the premature infants by prophylactic use of antibiotics. METHODS Retrospectively collect 409 premature infants admitted to the neonatal intensive care unit (NICU) of First Hospital of Jilin University between 1st January in 2009 and 31th December in 2011, who meet inclusion(More)
OBJECTIVE To investigate the permeability of β-NGF through blood-brain-barrier (BBB) in neonatal and adult rats, and the spatial distribution of β-NGF in different brain regions in hypoxic-ischemic (HI) and normal neonatal rats. METHODS To investigate the overall permeability of β-NGF through BBB, β-NGF labeled with I125 was injected into adult rats,(More)
Some complications induced by transient tachypnea of the newborn (TTN) threaten the lives of newborns, medical records of 1354 cases of TTN were analyzed in order to summary the clinical characteristics of TTN in different gestational age(GA). The cases were divided into 4 groups according to GA, including small GA preterm infants, near-term infants, term(More)
Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease in neonates, particularly in preterm infants. The interleukin (IL) 23/IL17 axis has been shown to play an important role in the gastrointestinal inflammation. However, the association of gene polymorphisms in the IL23/IL17 axis and the development of NEC remains unknown. In(More)