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OBJECTIVE To compare biochemical recurrence (BCR)-free survival and predictors of BCR in intermediate-risk (IR) and high-risk (HR) patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) vs open radical prostatectomy (ORP). MATERIALS AND METHODS We conducted a retrospective study on 1336 men with D'Amico IR or HR prostate cancer who(More)
BACKGROUND Hematuria is a common clinical finding and represents the most frequent presenting sign of bladder cancer. The American Urological Association recommends cystoscopy and abdomino-pelvic imaging for patients aged more than 35 years. Nonetheless, less than half of patients presenting with hematuria undergo proper evaluation. We sought to identify(More)
PURPOSE We determined the extent to which complications as well as number of hospital-free days within 30 and 90 days of surgery predicted health related quality of life 1 year after radical cystectomy. MATERIALS AND METHODS We used data from a prospective health related quality of life study using a validated instrument, the Vanderbilt Cystectomy(More)
We previously found loss of forkhead box A1 (FOXA1) expression to be associated with aggressive urothelial carcinoma of the bladder, as well as increased tumor proliferation and invasion. These initial findings were substantiated by The Cancer Genome Atlas, which identified FOXA1 mutations in a subset of bladder cancers. However, the prognostic significance(More)
OBJECTIVE To evaluate predictors of understaging in patients with presumed non-muscle-invasive bladder cancer (NMIBC) identified on transurethral resection of bladder tumour (TURBT) who underwent radical cystectomy (RC) with attention to the role of a restaging TURBT. PATIENTS AND METHODS We retrospectively evaluated 279 consecutive patients with(More)
BACKGROUND Differences in quality of care may contribute to racial variation in outcomes of bladder cancer (BCa). Quality indicators in patients undergoing surgery for BCa include the use of high-volume surgeons and high-volume hospitals, and, when clinically indicated, receipt of pelvic lymphadenectomy, receipt of continent urinary diversion, and(More)
BACKGROUND SOX2 is a member of SOX (SRY-related high mobility group box) family of transcription factors. METHODS In this study, we examined the expression of SOX2 in murine and human prostatic specimens by immunohistochemistry. RESULTS We found that SOX2 was expressed in murine prostates during budding morphogenesis and in neuroendocrine (NE) prostate(More)
BACKGROUND Female gender and black race are associated with delayed diagnosis and inferior survival in patients with bladder cancer. OBJECTIVE We aimed to determine the association between gender, race, and evaluation of microscopic hematuria (an early sign of bladder cancer). DESIGN AND PARTICIPANTS This was a cohort study using a 5 % random sample of(More)
BACKGROUND Rapid response teams (RRT) are used to prevent adverse events in patients with acute clinical deterioration, and to save costs of unnecessary transfer in patients with lower-acuity problems. However, determining the optimal use of RRT services is challenging. One method of benchmarking performance is to determine whether a department's event rate(More)
BACKGROUND The management of genitourinary malignancies requires a multidisciplinary care team composed of urologists, medical oncologists, and radiation oncologists. A genitourinary (GU) oncology clinical database is an invaluable resource for patient care and research. Although electronic medical records provide a single web-based record used for clinical(More)