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sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
TLDR
By identifying potential off-target sites in silico, the sgRNAcas9 allows the selection of more specific target sites and aids the identification of bona fide off- target sites, significantly facilitating the design of sg RNA for genome editing applications.
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Emerging roles for PIWI proteins in cancer.
TLDR
PIWI proteins are linked to the hallmarks of cancer defined by Weinberg and Hanahan, such as cell proliferation, anti-apoptosis, genomic instability, invasion and metastasis, which provides new possibilities for anticancer therapies through the targeting of PIWI proteins.
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Existing bitter medicines for fighting 2019‐nCoV‐associated infectious diseases
TLDR
It is suggested that a cocktail‐like recipe of existing bitter drugs may help doctors to fight this catastrophic disease and that the general public may drink or eat bitter substances, such as coffee, tea, or bitter vegetables, to reduce the risk of infection.
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CRISPR/Cas9‐mediated genome editing reveals the synergistic effects of β‐defensin family members on sperm maturation in rat epididymis
TLDR
It is suggested that Defb family members affect sperm maturation by a synergistic pattern in the epididymis, similar to how CRISPR/Cas9‐mediated genome editing reveals the synergistic effects of β‐defensin family members on spermmaturation in rat epidIDymis.
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A convenient system for highly specific and sensitive detection of miRNA expression.
TLDR
A new system for detecting miRNA expression is described, which can distinguish miRNA from its precursor and has single-nucleotide resolution and hasSingle molecule and multiplex detection potential.
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DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins
TLDR
The results suggest that DICER1 plays an important role in transcription of β-defensin genes, which are associated with the natural antibacterial properties in a microRNA-independent manner, and further impacts the male fertility.
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Rediscovery of caffeine: an excellent drug for improving patient outcomes while fighting WARS.
TLDR
It is found that caffeine can fight WARS by acting on multiple organs, which may lead to prevent the virus from entering the cell, stimulate the phagocytosis of macrophages, enhance breathing, and inhibit the cytokine storm.
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Decreased expression of piR-35413 in human papillary thyroid cancer.
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K-SEIR-Sim: A simple customized software for simulating the spread of infectious diseases
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Improved dot blotting for small RNA detection.
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