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Identification of sulfation sites of metabolites and prediction of the compounds’ biological effects
This work represents the first example of a high-throughput analysis that can identify the structure of sulfated metabolites and predict their biological effects, with a 97% success rate.
Bioactive 18(4 → 3)-abeo-abietanoid derivatives from the leaves of Tripterygium wilfordii
Tripterlides A–F (1–6), six new abietane diterpenoid derivatives, together with six known abietane diterpenoids (7–12) were obtained from the leaves of Tripterygium wilfordii. Tripterlides A–C (1–3)
Anti-inflammatory sesquiterpene derivatives from the leaves of Tripterygium wilfordii.
In an in vitro bioassay, compounds 1, 9, 11, 13, 14, and 18 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages at 5 μM; all compounds were inactive when tested against five human cancer cell lines.
Phenanthrenequinone enantiomers with cytotoxic activities from the tubers of Pleione bulbocodioides.
Eight new phenanthrenequinones (four pairs of enantiomers), named bulbocodioidins A-D (1-4), have been isolated from the ethanolic extract of tubers of Pleione bulbocidioides by extensive NMR analysis combined with experimental and calculated ECD data analyses.
Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs
Methyl 2-O-(4-O-β- d-galactopyranosyl)-β-d-glucopyranoylbenzoate showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo, and structure–activity relationships within these compounds were discussed.
[Chemical constituents from Pleione yunnanensis].
The chemical constituents from pseudobulbs of Pleione yunnanensis, one of the source of traditional Chinese medicine "Shancigu", were investigated by various chromatography methods, including silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC.
[Studies on glucosyloxybenzyl 2-isobutylmalates of Pleione bulbocodioides].
Ten glucosyloxybenzyl 2-isobutylmalates and one benzyl alcohol glycoside were isolated from the dry tuber of Pleione bulbocodioides, which is a specie of Orchidaceae family and its dry tuber is one