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BACKGROUND Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. METHODS We genotyped more than(More)
BACKGROUND Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis.(More)
To provide a resource for assessing continental ancestry in a wide variety of genetic studies, we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs). The markers were chosen for informativeness, genome-wide distribution, and genotype reproducibility on two platforms (TaqMan assays and Illumina arrays). We analyzed(More)
This paper describes a workflow manager developed and deployed at Yahoo called Nova, which pushes continually-arriving data through graphs of Pig programs executing on Hadoop clusters. (Pig is a structured dataflow language and runtime for the Hadoop map-reduce system.) Nova is like data stream managers in its support for stateful incremental processing,(More)
  • Chao Tian
  • 2013 IEEE International Symposium on Information…
  • 2013
Exact-repair regenerating codes are considered for the case (n, k, d) = (4, 3,3), for which a complete characterization of the rate region is provided. This characterization answers in the affirmative the open question whether there exists a non-vanishing gap between the optimal bandwidth-storage tradeoff of the functional-repair regenerating codes (i.e.,(More)
Admixture mapping requires a genomewide panel of relatively evenly spaced markers that can distinguish the ancestral origins of chromosomal segments in admixed individuals. Through use of the results of the International HapMap Project and specific selection criteria, the current study has examined the ability of selected single-nucleotide polymorphisms(More)
European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry. A second PC further separated Italian, Spanish,(More)
We provide a complete characterization of the rate-distortion region for the multistage successive refinement of the Wyner-Ziv source coding problem with degraded side informations at the decoder. Necessary and sufficient conditions for a source to be successively refinable along a distortion vector are subsequently derived. A source-channel separation(More)
MapReduce is an important programming model for building data centers containing ten of thousands of nodes. In a practical data center of that scale, it is a common case that I/O-bound jobs and CPU-bound jobs, which demand different resources, run simultaneously in the same cluster. In the MapReduce framework, parallelization of these two kinds of job has(More)
We introduce a new class of multiple description scalar quantizer (MDSQ), which will be referred to as the modified MDSQ (MMDSQ). The structure of MMDSQ is fundamentally different from the MDSQ proposed by Vaishampayan. Analysis shows that at high rates for sources with smooth pdfs, MMDSQ achieves the same performance as entropy-constrained MDSQ using a(More)