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—The requirement to reduce the computational cost of evaluating a point probability density estimate when employing a Parzen window estimator is a well-known problem. This paper presents the Reduced Set Density Estimator that provides a kernel-based density estimator which employs a small percentage of the available data sample and is optimal in the L 2(More)
We investigated the emergence of discriminative responses to pitch by recording 2-, 3-, and 4-month-old infants' electro-encephalogram responses to infrequent pitch changes in piano tones. In all age groups, infants' responses to deviant tones were significantly different from responses to standard tones. However, two types of mismatch responses were(More)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are encoded by HCN1-4 gene family and have four subtypes. These channels are activated upon hyperpolarization of membrane potential and conduct an inward, excitatory current Ih in the nervous system. Ih acts as pacemaker current to initiate rhythmic firing, dampen dendritic(More)
Aberrant matrix deposition is a hallmark of pulmonary fibrosis and is characterized by an imbalance between matrix deposition and degradation. We have previously shown that mice harboring a conditional deletion of the GTP-binding protein, Rac1, in macrophages are protected from asbestos-induced pulmonary fibrosis. To investigate the contribution of aberrant(More)
Previous studies have reported two types of event-related potential (ERP) mismatch responses in infants to infrequent auditory changes: a broad discriminative positivity in younger infants and a negativity resembling adult mismatch negativity (MMN) in older infants. In the present study, we investigated whether the positive discriminative slow wave and the(More)
A semantic link peer-to-peer (P2P) network specifies and manages semantic relationships between peers' data schemas and can be used as the semantic layer of a scalable Knowledge Grid. The proposed approach consists of an automatic semantic link discovery method, a tool for building and maintaining P2P semantic link networks (P2PSLNs), a semantic-based peer(More)
In order to process speech and music, the auditory cortex must learn to process patterns of sounds. Our previous studies showed that with a stream consisting of a repeating (standard) sound, younger infants show an increase in the amplitude of a positive slow wave in response to occasional changes (deviants) in pitch or duration, whereas older infants show(More)
A strain CSCr-3 with high Cr(VI)-reducing ability under alkaline conditions was isolated from a chromium landfill and identified as Ochrobactrum sp. on the basis of 16S rRNA gene sequence analysis. The cells were rod shaped, Gram-negative and motile. The physiological characteristics and Cr(VI)-reduction of the strain were also studied. The results showed(More)
Automated currency validation requires a decision to be made regarding the authenticity of a banknote presented to the validation system. This decision often has to be made with little or no information regarding the characteristics of possible counterfeits as is the case for issues of new currency. A method for automated currency validation is presented(More)
The NSD (nuclear receptor SET domain-containing) family members, consisting of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1), are SET domain-containing methyltransferases and aberrant expression of each member has been implicated in multiple diseases. They have specific mono- and dimethylase activities for H3K36, whereas play nonredundant roles during(More)