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[Costimulatory molecule CD40 expression in thyroid tissue of Graves' disease patients and its immune pathogenetic significance].
The expression of CD40 on infiltrated lymphocytes and TFC were detected in Graves' disease but not in non-toxic goiter patient tissues, and its costimulatory signal may take part in the immunopathologic mechanism of Graves’ disease. Expand
LncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop
It is revealed that lncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop, which might do help to the pursuit of better PC treatment. Expand
Low expression of PDK1 inhibits renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition through inhibition of the PI3K-PDK1-Akt pathway.
Key observations of this study provide evidence suggesting that high expressions of PDK1 are found in RCC, while highlighting that silencing PDK 1 could inhibit RCC cell proliferation, migration, invasion and EMT by repressing the PI3K-PDK1-Akt pathway. Expand
[Establishment and biological characterization of 5-fluorouracil-resistant human colon cancer HT-29/5-FU cell line].
- Tingting Qiu, Xiaojun Xiang, +6 authors J. Xiong
- Biology, Medicine
- Xi bao yu fen zi mian yi xue za zhi = Chinese…
- 1 March 2015
The biological characters of HT-29/5-FU cell line may play an important role in 5-FU-resistant mechanisms, which may also contribute to elucidate the potential mechanisms of tumor drug resistance as well as resistance reversal. Expand
Long non-coding RNA 00858 knockdown alleviates bladder cancer via regulation of the miR-3064-5p/CTGF axis
Mechanistically, LINC00858 functioned as a competitive RNA to increase the expression level of oncogene CTGF by sequestering miR-3064-5p and inhibited the proliferation, migration and invasion of bladder cancer cells via regulation of the miR/CTGF axis. Expand
miR-let-7 a suppress cell invasion and migration via the depressing PKM 2 in prostatic cancer
Objective: Some cancer reports found that miR-let-7a overexpression could suppress cancer cell biological activities M2 splice isoform of pyruvate kinase (PKM2) down-regulation, however, the… Expand
Effect of Yes Associated Protein 1 Silence on Proliferation and Apoptosis of Bladder Cancer Cells
- Gaoliang Wu, Chao Hao, Xueliang Qi, Jianqiang Nie
- Journal of Biomaterials and Tissue Engineering
- 1 May 2021
Findings provided the first evidence that YAP knockdown could inhibit cell proliferation and induce cell apoptosis of bladder cancer cells. Expand
A novel method to identify and isolate proliferative inflammatory atrophy (PIA) clusters and to extract high-quality PIA RNA.
- Yibing Wang, Chao Hao, +5 authors Gongxian Wang
- Biology, Medicine
- International journal of clinical and…
- 1 April 2015
The present study established a valid method to discover molecular evidence in support of the correlation between PIA and the development of PCa by isolated PIA by manual microdissection of cryosections stored in liquid nitrogen from clinical radical prostatectomy. Expand
The novel role of tumour suppressor p14ARF in tumour immunology to induce inflammatory response by enhancing SUMOylation
ARF has emerged as a potent up-regulator of global intracellular SUMOylation, independent of p53 activity, and the functional consequences to cancer aetiology remain to be elucidated. Expand
Effects of inhibition of miR-221 expression on proliferation and apoptosis of bladder cancer cells
Inhibition of miR-221 expression can suppress the proliferation of bladder cancer cells and induce apoptosis. Expand