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Having gained a tremendous amount of popularity since its introduction in 2006, tract-based spatial statistics (TBSS) can now be considered as the standard approach for voxel-based analysis (VBA) of diffusion tensor imaging (DTI) data. Aiming to improve the sensitivity, objectivity, and interpretability of multi-subject DTI studies, TBSS includes a(More)
There is accumulating evidence that at current acquisition resolutions for diffusion-weighted (DW) MRI, the vast majority of white matter voxels contains "crossing fibers", referring to complex fiber configurations in which multiple and distinctly differently oriented fiber populations exist. Spherical deconvolution based techniques are appealing to(More)
PURPOSE Recent literature shows that diffusion tensor properties can be estimated more accurately with diffusion kurtosis imaging (DKI) than with diffusion tensor imaging (DTI). Furthermore, the additional non-Gaussian diffusion features from DKI can be sensitive markers for tissue characterization. Despite these benefits, DKI is more susceptible to data(More)
Diffusion MRI and tractography allow for investigation of the architectural configuration of white matter in vivo, offering new avenues for applications like presurgical planning. Despite the promising outlook, there are many pitfalls that complicate its use for (clinical) application. Amongst these are inaccuracies in the geometry of the diffusion profiles(More)
In this chapter erosion is generalized to the space of diffusion weighted MRI data. This is done effectively by solving a Hamilton-Jacobi-Bellman (HJB) system (erosion) on the coupled space of three dimensional positions and orienta-tions, embedded as a quotient in the group of three dimensional rigid body motions. The solution to the HJB equations is given(More)
OBJECTIVE To explore the galvanic-evoked vestibulospinal reflex in health and disease. METHODS Vestibular-evoked whole-body movement was measured in 60 controls and eight patients with bilateral vestibular impairment, using 1mA × 2s Galvanic Vestibular Stimulation (GVS). The displacement (s) and velocity (v) of 7 markers placed on the head, neck,(More)
OBJECTIVES To investigate both cross-sectional and time-related changes of striatal and whole-brain microstructural properties in different stages of Huntington's disease (HD) using diffusion tensor imaging. EXPERIMENTAL DESIGN From the TRACK-HD study, premanifest gene carriers (preHD), early manifest HD and controls were scanned at baseline and 2-year(More)
Fiber tractography plays an important role in exploring the architectural organization of fiber trajectories, both in fundamental neuroscience and in clinical applications. With the advent of diffusion MRI (dMRI) approaches that can also model "crossing fibers", the complexity of the fiber network as reconstructed with tractography has increased(More)
Diffusion magnetic resonance (MR) imaging is sensitive to microstructural changes in tissue. Diffusion tensor MR imaging, the most commonly used method, can estimate the magnitude and anisotropy of diffusion. These tensor-based diffusion parameters have been shown to change in many neuropathologic conditions. Recent advances in diffusion MR imaging(More)
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