Chantal A. A. Van der Graaf

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Toll-like receptors (TLRs) have been identified as a major class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces signals responsible for the activation of the innate immune response. Recent studies have demonstrated a crucial(More)
Toll-like receptors (TLRs) are membrane-spanning receptors that play a key role in the innate immune system. . They play an important role in providing innate immunity. TLR1 is one such protein that belongs to this family . It recognizes pathogen-associated molecular pattern and is specific for gram-positive bacteria. TLR1 dimerizes with TLR2 and identifies(More)
The contribution of the enzymes CYP2D6 and CYP2C19 to the metabolism of artemether was evaluated in a cross-over study in seven healthy adult Caucasian subjects. The pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin were compared when given 100 mg artemether orally alone or in combination with either CYP2D6-inhibitor(More)
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