Changzhong Chen

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  • Pixu Liu, Hailing Cheng, Stephanie Santiago, Maria Raeder, Fan Zhang, Adam Isabella +10 others
  • 2011
PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy 1–4 , making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-targeted therapy, we constructed a mouse model of breast cancer(More)
Our recent study showed a dose-response relationship between environmental tobacco smoke (ETS) and the risk of early pregnancy loss. Smoking is known to affect female reproductive hormones. We explored whether ETS affects reproductive hormone profiles as characterized by urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E1C) levels. We(More)
—This paper introduces an automatic approach for the estimation of registration parameters between successive viewpoints visited by a laser range sensor. The proposed technique works directly on the raw range measurements and does not require any external device for pose estimation nor any sophisticated feature extraction or triangular mesh computation.(More)
OBJECTIVE Many studies have indicated that intra-abdominal pressure (IAP) is positively correlated with central venous pressure (CVP) in severe cases. However, although elevated IAP is common in patients with severe acute pancreatitis (SAP), its relationship with CVP remains unclear. Our study aimed to investigate the association of IAP with CVP in(More)
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