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CONTEXT Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes. OBJECTIVE To investigate whether the association between maternal cigarette smoking and infant birth weight differs by polymorphisms of 2 maternal metabolic genes: CYP1A1 and GSTT1. DESIGN, SETTING, AND PARTICIPANTS Case-control study(More)
PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy 1–4 , making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-targeted therapy, we constructed a mouse model of breast cancer(More)
In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes , we conducted a case-control association study among 132 couple-pairs from northern China. The geno-The DD frequency was significantly higher in the case group than in the control group (␹ 2 1 ‫؍‬ 4.77, P ‫؍‬ 0.03), suggesting that the DD genotype is(More)
Our recent study showed a dose-response relationship between environmental tobacco smoke (ETS) and the risk of early pregnancy loss. Smoking is known to affect female reproductive hormones. We explored whether ETS affects reproductive hormone profiles as characterized by urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E1C) levels. We(More)
—This paper introduces an automatic approach for the estimation of registration parameters between successive viewpoints visited by a laser range sensor. The proposed technique works directly on the raw range measurements and does not require any external device for pose estimation nor any sophisticated feature extraction or triangular mesh computation.(More)
This paper describes a new algorithm for the analysis of high-speed interconnects characterized by frequency-dependent per-unit-length parameter matrices. The proposed technique is based on using the idea of integrated congruence transform to construct a reduced-order system for the interconnect. The reduced-order system offers simple time-domain ordinary(More)
OBJECTIVE Many studies have indicated that intra-abdominal pressure (IAP) is positively correlated with central venous pressure (CVP) in severe cases. However, although elevated IAP is common in patients with severe acute pancreatitis (SAP), its relationship with CVP remains unclear. Our study aimed to investigate the association of IAP with CVP in(More)
This paper presents a robust method for guaranteed passive macromodeling of high-speed interconnects characterized by multiconductor transmission lines with frequency-dependent per-unit-length (FD-PUL) parameters, using integrated-congruence-transformation-based model-order-reduction techniques. For this purpose, a new formulation is developed to directly(More)