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Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O(6)-methylguanine DNA methyltransferase) and APNG (alkylpurine-DNA-N-glycosylase) are key enzymes capable of repairing temozolomide-induced DNA damages and their levels in tissue are(More)
Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy efficacy. Biosensing strategies using magnetic nanoparticles (MNPs) have recently received considerable attention, since they offer unique(More)
2012 ii To Dad, Mom, my brother, and friends... iii ACKNOWLEDGEMENTS I would like to thank my advisor Prof. Michael Flynn for guiding and encouraging me technically and personally during the whole time in Ann Arbor. He inspired and motivated me with his passion and intelligence, and I would never have been able to finish my research without his care and(More)
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