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High resolution melting analysis for epidermal growth factor receptor mutations in formalin-fixed paraffin-embedded tissue and plasma free DNA from non-small cell lung cancer patients.
TLDR
The results show that HRM analysis has the advantage of small tumor sample need and further research into appropriate methods and analysis needs to be performed before HRM for plasma free DNA could be accepted as an option in diagnostic or screening settings.
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The Function Role of miR-181a in Chemosensitivity to Adriamycin by Targeting Bcl-2 in Low-Invasive Breast Cancer Cells
TLDR
At least in part, the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of the enhanced adriamycin-induced apoptosis via targeting Bcl-2.
View on PubMed
Next-generation sequencing-based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her-2 and TP53 mutations in patients with non-small cell lung cancer
TLDR
The performance of NGS assays in routine clinical detection may be useful in determining the treatment decisions in NSCLC patients, suggesting the high degree of agreement of reportable variants is proposed in both NGS and ddPCR analysis.
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Protective Effect of Resveratrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice
TLDR
It is found that the pretreatment with resveratrol can effectively protect mice against LPS‐induced ALI and may suggest resver atrol as a potential therapeutic agent for treating ALI in the future.
View on Wiley
Hepcidin in tumor‐related iron deficiency anemia and tumor‐related anemia of chronic disease: pathogenic mechanisms and diagnosis
TLDR
The objective was to evaluate the use of hepcidin to discriminate tumor‐related IDA and ACD and to investigate the mechanism of action of hePCidin in these anemias.
View on Wiley
Circulating tumor DNA detection: A potential tool for colorectal cancer management
TLDR
The aim of the current review was to explore the clinical applications of ctDNA in patients with CRC, including early detection and screening, medication guidance, resistance prediction, and residual lesion and recurrence monitoring.
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Cytokine-induced killer cells as a feasible adoptive immunotherapy for the treatment of lung cancer
TLDR
The results suggested that combination of immunotherapy with traditional therapy will be a feasible and promising method for the treatment of lung cancer.
View on Springer
Long noncoding RNA and mRNA profiling in cetuximab‐resistant colorectal cancer cells by RNA sequencing analysis
TLDR
The results provide essential data regarding differentially expressed lncRNAs and mRNAs in cetuximab‐resistant cells, which may provide new potential candidates for cetUXimab therapy.
View on Wiley
The somatic mutation landscape of Chinese Colorectal Cancer
TLDR
It is found that Chinese CRC were hypermutated, which were enriched in ECM-receptor interaction, antigen processing and presentation, and focal adhesion, which may expand the understanding of disease mechanisms and provide an alternative personalized treatment for Chinese CRC patients.
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Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR‐TKI treatment
TLDR
It is found that T0901317 could make natural EGFR‐TKI‐resistant A549 human lung cancer cells sensitive to EGFR•TKI treatment and that this was dependent on LXRβ expression.
View on Wolters Kluwer
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