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Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing to the uncertainty regarding the(More)
During Caenorhabditis elegans development, the HSN neurons and the right Q neuroblast and its descendants undergo long-range anteriorly directed migrations. Both of these migrations require EGL-20, a C. elegans Wnt homolog. Through a canonical Wnt signaling pathway, EGL-20/Wnt transcriptionally activates the Hox gene mab-5 in the left Q neuroblast and its(More)
A fast H.264 Intra prediction mode selection scheme is proposed in this work. The objective is to reduce the encoder complexity without significant rate-distortion performance degradation. The proposed method uses spatial and transform domain features of the target block jointly to filter out the majority of candidate modes. This is justified by examining(More)
A fast mode decision method for Intra prediction in H.264 is proposed in this work to reduce the encoder complexity. The proposed algorithm adopts a multi-stage sequential mode decision process that uses joint spatial and transform domain features to filter out unlikely candidate modes and, in the final stage, a simplified rate-distortion optimization(More)
BACKGROUND Developmental, physiological and tissue engineering studies critical to the development of successful myocardial regeneration therapies require new ways to effectively visualize and isolate large numbers of fluorescently labeled, functional cardiomyocytes. METHODOLOGY/PRINCIPAL FINDINGS Here we describe methods for the clonal expansion of(More)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the predominant loss of motor neurons (MNs) in primary motor cortex, the brainstem, and the spinal cord, causing premature death in most cases. Minimal delay of pathological development by available medicine has prompted the search for novel therapeutic treatments to cure(More)
Induced pluripotent stem cell (iPSC) technology has shown us great hope to treat various human diseases which have been known as untreatable and further endows personalized medicine for future therapy without ethical issues and immunological rejection which embryonic stem cell (hES) treatment has faced. It has been agreed that iPSCs knowledge can be(More)
PURPOSE This study evaluated the spontaneous healing capacity of surgically produced cranial defects in rabbits with different healing periods in order to determine the critical size defect (CSD) of the rabbit cranium. METHODS Thirty-two New Zealand white rabbits were used in this study. Defects of three sizes (6, 8, and 11 mm) were created in each of 16(More)
We investigate the encoding speed improvement for H.264 with a special focus on fast intra-prediction mode selection in this work. It is possible to adopt the rate-distortion (RD) optimized mode in H.264 to maximize the coding gain at the cost of a very high computational complexity. To reduce the complexity associated with the intra-prediction mode(More)