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Biomimetic porous scaffolds for bone tissue engineering
Abstract Increased use of reconstruction procedures in orthopedics, due to trauma, tumor, deformity, degeneration and an aging population, has caused a blossom, not only in surgical advancement, butExpand
Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration.
The results obtained suggest that CMPC, having met the basic requirements of bone tissue engineering, might have a significant clinical advantage over CPC, and may have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery. Expand
Development of magnesium calcium phosphate biocement for bone regeneration
The results demonstrated that the MCPB had a good ability to support cell attachment, proliferation and differentiation, and exhibited good cytocompatibility. Expand
Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells.
The effect of the particle size of the HAPN on the anti-tumor activity, apoptosis-induction and the levels of the apoptotic signaling proteins in human hepatoma HepG2 model cells is investigated to provide new means to modulate the cellular behaviors of HAPn and to guide the design of H APN-based delivery and therapeutic systems. Expand
Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration.
Histological evaluation confirmed that the micro/ma-MCP scaffolds improved the efficiency of new bone regeneration, and exhibited excellent biocompatibility, biodegradability and faster and more effective osteogenesis in vivo. Expand
In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content
It is demonstrated that PEG 10 wt% modified PLA HbP with suitable size, surface charge, and surface hydrophilicity, has a promising potential as long-circulating oxygen carriers with desirable biocompatibility and biofunctionality. Expand
Facile synthesis of monodisperse superparamagnetic Fe3O4 Core@hybrid@Au shell nanocomposite for bimodal imaging and photothermal therapy.
The as-prepared nanocomposite is demonstrated to have a great potential for magnetic resonance imaging (MRI)-guided, focused photothermal tumor therapy under near-IR laser radiation. Expand
Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo.
Low dose of 2-N, 6-O-sulfated chitosan (26SCS) showed significant enhancement on the alkaline phosphatase (ALP) activity and the mineralization formation induced by BMP-2, as well as the expression of ALP and osteocalcin mRNA, indicating that 26SCS could be used as the synergistic factor of B MP-2 for bone regeneration. Expand
Osteogenic Responses to Different Concentrations/Ratios of BMP-2 and bFGF in Bone Formation
Results show that a combination of rhBMP-2 and bFGF effectively induces early BMSC proliferation and differentiation in vitro and on ectopic bone formation in rats. Expand
Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds.
Observations suggest that sulfated chitosan coating could enhance the release profile of CDHA/BMP-2 composite in vitro and promote new bone formation in vivo and the hybrid CD HA/B MP-2/SCS system is a promising growth factor delivery strategy for bone regeneration. Expand